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Common genetic variation and novel loci associated with volumetric mammographic density
Brand, Humphreys, Li, Karlsson, Hall, Czene
“Apart from identifying three novel loci, we demonstrate that at least 25% of the MD variance is explained by common genetic variation with h2 SNP/h2 ratios varying between dense and nondense MD components … A fully automated method such as Volpara has clear benefits in terms of a standardized and objective MD measurement.”
Volumetric Mammographic Density: Heritability and Association With Breast Cancer Susceptibility Loci
Brand, Humphreys, Thompson, Li, Eriksson, Hall, Czene
“Our results support the high heritability of mammographic density, though estimates are weaker for absolute than percent dense volume.”
Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study
Borgquist, Rosendahl, Czene, Bhoo-Pathy, Dorkhan, Hall, Brand
“The consistency in direction of association for insulin treatment and the insulin genetic score with the absolute dense volume suggest a causal influence of long term increased insulin exposure on mammographic dense breast tissue.”
Using an automated measure of breast density to explore the association between ethnicity and mammographic density in Australian women
Bell, Evans, Fox, Pridmore
“Mammographic density as assessed by VDG was positively associated with ever exposure to MHT and inversely associated with age. Being born in a country with predominantly Asian ancestry was associated with higher VDG when controlled for age and MHT exposure.”
Adiposity during early adulthood, changes in adiposity during adulthood, attained adiposity, and mammographic density among premenopausal women
Alimujiang, Appleton, Colditz, Toriola
“In this cross-sectional study, all adiposity measures were significantly inversely associated with VPD, but positively associated with both DV and NDV among premenopausal women … We assessed mammographic density using Volpara which provides volumetric mammographic density measures.”
Breast Tissue Organisation and its Association with Breast Cancer Risk
Ali, Czene, Eriksson, Hall, Humphreys
“Our findings are consistent with the notion that fibroglandular and adipose tissue plays a role in breast cancer risk and, more specifically, they suggest that fatty tissue in the lower quadrants and the absence of density in the retromammary space, as shown in mediolateral oblique images, are protective against breast cancer.”
Identification of two novel mammographic density loci at 6Q25.1
Brand, Li, Humphreys, Karlsson, Eriksson, Ivansson, Hall, Czene
“…we identified two novel MD loci at 6q25.1 in a large scale genotyping effort of semi- and fully automated MD measures, which have previously been associated with breast cancer risk.”
Background risk of breast cancer influences the association between alcohol consumption and mammographic density
Trinh, Christensen, Brand, Cuzick, Czene, Sjölander, Bälter, Hall
“…increasing alcohol consumption was associated with higher absolute dense volume (cm3) and percent dense volume (%). The association between alcohol consumption and absolute dense volume was most pronounced among women with the highest (≥5%) Tyrer-Cuzick 10-year risk.”
Background risk of breast cancer and the association between physical activity and mammographic density
Trinh, Eriksson, Darabi, Bonn, Brand, Cuzick, Czene, Sjölander, Bälter, Hall
“…higher levels of physical activity were associated with lower absolute dense volume and nondense volume, but seemed to be associated with higher percent dense volume… absolute dense volume seemed to vary according to the risk of developing breast cancer in the next 10 years…Volumetric measures are therefore expected to capture the actual amount of fibroglandular tissue in the breast more precisely.”
Automated Measurement of Volumetric Mammographic Density: A Tool for Widespread Breast Cancer Risk Assessment
Brand, Czene, Shepherd, Leifland, Heddson, Sundbom, Eriksson, Li, Humphreys, Hall
“Percent and absolute dense volumes as obtained with Volpara are associated with established determinants of mammographic density as well as breast cancer risk… our results suggest that automated measurement of volumetric mammographic density can be used as part of screening programs to provide risk and masking information that could be used to alter woman’s clinical management…”
