Publications

“Percent and absolute dense volumes as obtained with Volpara are associated with established determinants of mammographic density as well as breast cancer risk… our results suggest that automated measurement of volumetric mammographic density can be used as part of screening programs to provide risk and masking information that could be used to alter woman’s clinical management…”

“Volumetric mammographic density, automatically measured on digital mammograms, impacts screening performance measures along the same patterns as established with ACR breast density categories.”

“There appears to be geographic variation in mammographic density in the Netherlands, emphasizing the importance of including breast density as parameter in the evaluation of screening performance.”

“Variation in dense volume for post-menopausal Asian and Caucasian women reflects population differences in breast cancer risk, and these are attributed to differences in height, weight, and parity. Further research is needed to identity a suitable mammographic density measure as a biomarker for breast cancer risk among pre-menopausal Asian women.”

“These preliminary data suggest that remodelling, and hence stiffening, of the existing stromal collagen microarchitecture promotes high mammographic density within the breast. In turn, this aberrant mechanical environment may trigger neoplasia-associated mechanotransduction pathways within the epithelial cell population”

“Women with a history of infertility had higher absolute dense volume than other women. Among the infertile women, those who had gone through COS [controlled ovarian stimulation] had the highest absolute dense volume.”

“Volpara was robust to expected clinical variations, with errors in most investigated parameters giving limited changes in results…”

“VBD showed a highly significant positive correlation with visual assessment… Automated VBD is a reliable objective method to measure breast density.”

“Therefore, the use of automated software may help provide higher reproducibility, especially for patients with different bilateral breast densities… In conclusion, automated volumetric breast density measurement shows good agreement of BI-RADS density category as a quantitative method.”

“The categorization of serial mammograms in density classes is more consistent with automated software than with a mixed group of human readers. When using breast density to personalize screening protocols, assessment with software may be preferred over assessment by radiologists.”