Publications

“In particular, compared to Pakeha women, Ma¯ori women had higher levels of absolute volumetric density and Asian women had lower levels. For percentage breast density, Asian women had higher and Pacific women had lower breast density.”

“Increased MD is more strongly associated with H2P tumors when compared to
LA … Delineating risk factors specific to BC subtype may promote development of
individualized risk prediction models and screening strategies.”

“Mammographic density was determined both by breast imaging-reporting and data system (BI-RADS) classification and by an automated software program  (Volpara Solutions) … Mammographic density is not associated with an increased need for re-excision or resection of unnecessary margins at initial BCS.”

“All density measures showed a positive association with presence of cancer and all declined with age. The strongest effect was seen with Volpara absolute density, with a significant 3% (95% CI 1e5%) increase in risk per 10 cm3 of dense tissue. The effect of Volpara volumetric density on risk was stronger for large and grade 3 tumours.”

“The results of our continued evaluation of our screening sonography program confirm that screening breast sonography in women with dense breast tissue can detect otherwise occult malignancy, with a low biopsy rate.”

“Both the categoric and continuous measures of MBD obtained with the VolparaDensity tool were stronger risk factors than the visual BI-RADS categories (3.9-fold, 4.0-fold, and 3.6-fold).”

“Handheld screening breast sonography performed in women with dense breast tissue can aid in the detection of otherwise occult breast cancer, as we found 2 cancers in the study population, with an overall positive predictive value of 8%.”

“Women with extremely dense breasts (Volpara density grade 4), and a negative mammography result after double reading (Breast Imaging Reporting and Data System classification 1 or 2) were eligible for randomisation. After randomisation, only those women randomised to the intervention group (supplemental MRI examination) were informed and invited for the trial … Of women invited for MRI because of extremely dense breasts, 59% participated.”

“Since the model for calculating mean glandular dose (Volpara Analytics) includes a compensation factor for the measured breast density [17], it is likely that breast atrophy explains the observed significant decrease in mean glandular dose.”

“Raw mammographic images were acquired on two mammography imaging systems (General Electric and Hologic) one year apart and processed using VolparaDensity™ to obtain the Volpara Density Grade (VDG) and average volumetric breast density percentage (AvBD%). Visual BIRADS scores were also obtained from 20 expert readers. BIRADS scores for both systems showed strong positive correlation (ρ ¼ 0.904; p < 0.001), while the VDG (ρ ¼ 0.978; p < 0.001) and AvBD% (ρ ¼ 0.973; p < 0.001) showed stronger positive correlations.”